Aug 07, 2013 The Claisen condensation is a carboncarbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base, resulting in a keto ester or a diketone. It is named after Rainer Ludwig Claisen, who first published his work on the reaction in 1887. 4. 2 Use of the Claisen condensation in synthesis C bond formation, the reaction having a biological counterpart in the formation of keto esters via acetylcoenzyme A.
The value of the reaction is greatly enhanced if it can be made regioselective. the ClaisenSchmidt reaction. The aldol reaction is used extensively to synthesize new CC bonds. In a crossed aldol synthesis, two different aldehydes or ketones (or one ketone and one a student tests one procedure and compares it to a different procedure tested by another student. In synthesis route A, only half of the initial ketone The Claisen condensation is a carboncarbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base, resulting in a keto ester or a diketone.
It is named after Rainer Ludwig Claisen, who first published his work on the reaction ALDOL. 1 ORGANIC SYNTHESIS: ALDOL CONDENSATION REACTION TECHNIQUES REQUIRED: Filtration (Vacuum), Recrystallisation, Melting Point Determination OTHER DOCUMENTS: Experimental Procedure, Report Template, Spectra INTRODUCTION In an" aldol addition" reaction an enol or enolate of an aldehyde or ketone reacts with a second aldehyde or ketone forming a new carboncarbon bond Claisen ester condensation has much in common with the aldol reaction.
The first step involves the treatment of ethyl acetate with sodium ethoxide to form the enolate ion. Ethoxide is used instead of hydroxide because hydroxide would hydrolyse the ester.
An aldol condensation is a condensation reaction in organic chemistry in which an enol or an enolate ion reacts with a carbonyl compound to form a hydroxyaldehyde or hydroxyketone (an aldol reaction), followed by dehydration to give a conjugated enone.
Claisen Condensation The Claisen Condensation between esters containing hydrogens, promoted by a base such as sodium ethoxide, affords ketoesters. The driving force is the formation of the stabilized anion of the keto ester. Claisen condensation of diethyl succinate. Procedure: Use an Eppendorf pipet to add 2. 00 mL diethyl succinate to the cylindrical microwave reaction vessel provided. ring and imparts added stability.
The resulting product, 4phenyl3butene2one, is the result from a single aldol condensation reaction between benzaldehyde and acetone. Regioselectivity in Claisen condensation and aldol reaction. In the Claisen condensation, A should be the main product since the CH2 group is present thus corresponding the mechanism. Likewise for the aldol the simplest procedures just add Ba(OH)2 or NaOH to the substrate and heat. Everything there Claisen condensation reaction procedure manual reversible.
orthocresol The Claisen condensation differs from the aldol reaction in several important ways. (i) The aldol reaction may be catalyzed by acid or base, but most Claisen condensations require base. (ii) In contrast to the catalytic base used for aldol reactions, a full equivalent of base (or more) must be used for the Claisen condensation.